Letter to the Editor Meta-analysis of Aspirin for the Prevention of Preeclampsia: Do the Main Randomized Controlled Trials Support an Association between Low-dose Aspirin and a Reduced Risk of Developing Preeclampsia?
نویسندگان
چکیده
Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo São Paulo/SP, Brazil. Clinical and Toxicological Analysis Department, São Paulo University of Pharmaceutical Sciences Sao Paulo/SP, Brazil. Institute of Mathematics and Statistics, São Paulo University São Paulo/ SP, Brazil. Heart Institute (InCor), São Paulo University Medical School, São Paulo/ SP, Brazil. Email: [email protected] LETTER TO THE EDITOR
منابع مشابه
Prevention of preeclampsia with low-dose aspirin -- a systematic review and meta-analysis of the main randomized controlled trials.
The purpose of this paper is to evaluate the effectiveness of low-dose aspirin in the prevention of preeclampsia in low-risk and high-risk women. We identified randomized clinical trials of the use of low-dose aspirin to prevent preeclampsia through the PUBMED search engine, and through the Cochran Library database. Twenty-two studies met our inclusion criteria, and were divided according to th...
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Background: To evaluate the effect of aspirin on preeclampsia and fetal growth restriction (FGR) in obese pregnant women. Methods: A randomized clinical trial with 187 participants. Participants were allocated to either an intervention (aspirin; n=89) or control (placebo; n=98) group. In two groups, intervention was done from 13-20 until 34 weeks of pregnancy. Outcomes were preeclampsia and FG...
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Background: Preeclampsia is one of the most common causes of maternal mortality. This complication has been attempted to prevent preeclampsia. Many drug treatments have also been tested, including aspirin, one of the drugs prescribed to prevent preeclampsia. Therefore, the present study was designed to summarize the findings and co...
متن کاملEarly administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis.
OBJECTIVE To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia. METHOD A systematic review and meta-analysis of randomized controlled trials were performed. Women who were randomized to low-dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included. The outcomes of interest were preterm preeclampsia (delivery <37 week...
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BACKGROUND Preeclampsia and fetal growth restriction are major causes of perinatal death and handicap in survivors. Randomized clinical trials have reported that the risk of preeclampsia, severe preeclampsia, and fetal growth restriction can be reduced by the prophylactic use of aspirin in high-risk women, but the appropriate dose of the drug to achieve this objective is not certain. OBJECTIV...
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